Dedicated to transforming the care of people living with rare genetic disorders of obesity

"When Tysen was three he was fifty pounds, when Mike was three he was eighty pounds."

Mike and Tysen, father and son living with MC4R Pathway Heterozygous Obesity

Joan, wife to Mike and mother to Tysen, both diagnosed with MC4R Pathway Heterozygous Obesity

"Alström syndrome has a high impact on her weight...she constantly wants to eat and can't get enough."

Leigha, living with Alström syndrome

Breezy, mother of Leigha, diagnosed with Alström syndrome

"I think the biggest thing to try to get people to understand is the constant hunger issue."

Solomon and Adalissa, siblings living with Bardet-Biedl syndrome

Olivia, Mother of Adalissa and Solomon, both diagnosed with Bardet Biedl syndrome

"When Tysen was three he was fifty pounds, when Mike was three he was eighty pounds."

Joan, wife to Mike and mother to Tysen, both diagnosed with MC4R Pathway Heterozygous Obesity

Mike and Tysen, father and son living with MC4R Pathway Heterozygous Obesity
"Alström syndrome has a high impact on her weight...she constantly wants to eat and can't get enough."

Breezy, mother of Leigha, diagnosed with Alström syndrome

Leigha, living with Alström syndrome
"I think the biggest thing to try to get people to understand is the constant hunger issue."

Olivia, Mother of Adalissa and Solomon, both diagnosed with Bardet Biedl syndrome

Solomon and Adalissa, siblings living with Bardet-Biedl syndrome

We’re focused on the melanocortin-4 receptor (MC4R) pathway, which is responsible for regulating weight and hunger.


By targeting the MC4R pathway, we aim to develop therapeutics
for rare genetic disorders of obesity, including:

Proopiomelanocortin
(POMC) Deficiency Obesity
Leptin Receptor (LEPR)
Deficiency Obesity
Bardet-Biedl
Syndrome (BBS)
Alström
Syndrome
POMC or LEPR
Heterozygous Deficiency Obesity
Smith-Magenis
Syndrome
SRC1 Deficiency
Obesity
MC4R Deficiency
Obesity
SH2B1 Deficiency
Obesity

Our news

2021-04-07T08:00:00

Rhythm Pharmaceuticals to Present at 20th Annual Needham Virtual Healthcare Conference

2021-03-20T11:30:00

Rhythm Pharmaceuticals Presents New Data from Phase 2 Basket Study Showing Continued Weight Loss at Up to Nine Months in Patients with HET Obesity on Setmelanotide at ENDO 2021

2021-03-09T08:00:00

Rhythm Pharmaceuticals Announces Late-Breaking Data Presentations at ENDO 2021