BOARD OF DIRECTORS

Christian de la Tour
Mr. de la Tour is Chairman of Ipsen UK Companies. He has more than 25 years of experience in various commercial and corporate business development functions at Ipsen. Mr. de la Tour is a founding member and served as Vice President of Ipsen’s Corporate Business Development department, which he led from 1998 to 2009. His efforts were instrumental in Ipsen’s emergence as a leader in global pharmaceutical partnering. Mr. de la Tour holds a degree from Institut Superieur de Gestion business school in Paris.

Neil Exter
Neil Exter is a partner at Third Rock Ventures, where he plays an integral role in the formation, development, business strategy, and business development efforts of portfolio companies. He has more than 20 years of business development and strategic experience, facilitating the successful development and implementation of operations and collaborations across the spectrum of newly emerging and established biotech companies.
Prior to joining Third Rock Ventures, Mr. Exter was CBO of Alantos Pharmaceuticals and led the sale of that company to Amgen. Previously, he served as Vice President for Millennium Pharmaceuticals, where he directed in-licensing as well as mergers and acquisitions. Earlier in his career, he held various executive management roles in the high-technology industry, including tenures at Hewlett Packard and Wang Laboratories. Mr. Exter currently also serves as Interim Chief Business Officer of Foundation Medicine and is a board member of CytomX Therapeutics and Cibiem. He is a member of the Research Committee of Children's Hospital Boston, the investment committee of the Innovation Research Fund at Partners Healthcare, the Board of Directors of the New England Venture Capital Association, the Advisory Council of the Electrical and Computer Engineering Department at Cornell University, and the Board of Visitors of Columbia College. He holds an MBA as a Baker Scholar from Harvard Business School, an MS from Stanford University, and a BS from Cornell University.

Keith M. Gottesdiener, MD
Dr. Gottesdiener is Chief Executive Officer of Rhythm. He joined Rhythm after 16 years at Merck Research Laboratories. Dr. Gottesdiener joined Merck early clinical development in 1995, helping to transition compounds from the bench to the bedside and through to proof of concept. He held positions of increasing responsibility, eventually leading the early clinical development/clinical pharmacology department at Merck from 2001 through early 2006. From 2006-2011, he was a leader of Merck's late clinical development organization, first overseeing the development of Merck's infectious diseases and vaccine products through pivotal trials, registration, and life cycle management, including Gardasil™ (HPV Vaccine), Rotateq™ (rotavirus vaccine), Zostavax™ (zoster vaccine) and Isentress™ (HIV integrase inhibitor), among others. In 2008, Dr. Gottesdiener was appointed Late Stage Therapeutic Group Leader, and in that role led the late-stage clinical development efforts of Merck across all therapeutic areas. After the merger with Schering Plough in 2009, he continued as co-head of late development; most recently playing a leading role in the regulatory activities leading to the approval of boceprevir for Hepatitis C. Dr. Gottesdiener received his BA from Harvard College and his MD from the University of Pennsylvania. He completed his residency and fellowship at the Brigham and Women's Hospital-Beth Israel Medical Center-Dana Farber Cancer Institute Children's Hospital programs. After his fellowship, Dr. Gottesdiener did postdoctoral research in the laboratory of Dr. Jack Strominger at Dana Farber Cancer Institute working on the molecular immunology of the T-cell receptor. In 1986, he joined the faculty as an assistant professor at Columbia University, started an independent research laboratory with NIH RO-1 funding, focusing on gene transcription, and was Associate Clinical Professor of Medicine at the time he left to join Merck in 1995.

Vaughn Kailian
Vaughn Kailian is a Managing Director at MPM Capital. He joined MPM's Boston office in 2005 bringing unparalleled success in the stewardship of commercial biotechnology and pharmaceutical companies. From 2002 to 2004, Mr. Kailian served as Vice Chairman of Millennium Pharmaceuticals' Board of Directors and was head of the Millennium commercial organization. From 1990 to 2002, he served as Chief Exeutive Officer, President, and Director of COR Therapeutics. He became CEO of COR shortly after the company was founded, took the company public in 1991, raised almost $1 billion in public market capital, and led the company's $2 billion merger with Millennium in 2002. Earlier in his career, Mr. Kailian held various international and U.S. general management and commercial positions at Marion Merrell Dow and its predecessor companies, including President and General Manager, Merrell Dow USA; and Corporate Vice President of Global Commercial Development, Marion Merrell Dow. He is currently a Director of NicOx, Rhythm, Valeritas, and Xanodyne Pharmaceuticals and is also a member of the board of BIO Ventures for Global Health. Mr. Kailian holds a BA from Tufts University.

Ed Mathers
Mr. Mathers is a Partner at New Enterprise Associates (NEA), where he is focused on biotechnology and specialty pharmaceuticals investments. Prior to joining NEA, he most recently served as Executive Vice President, Corporate Development and Venture, at MedImmune, Inc. In this role, he was responsible for the company's licensing, M&A, and business development activities and led the company's venture capital subsidiary, MedImmune Ventures, Inc. Before joining MedImmune, he was Vice President, Marketing and Corporate Licensing and Acquisitions at Inhale Therapeutic Systems. Mr. Mathers spent 15 years at Glaxo Wellcome (GlaxoSmithKline), where he held sales and marketing positions of increasing responsibility. He started his career at Ortho Pharmaceuticals Corporation, a division of Johnson & Johnson, as a researcher. Mr. Mathers currently sits on the boards of directors of Intarcia Therapeutics, Satori Pharmaceuticals, Liquidia Technologies, and Plexxikon. He earned his bachelor's degree in Chemistry from North Carolina State University.