Clément, K., et al. Efficacy and safety of setmelanotide, an MC4R agonist, in individuals with severe obesity due to LEPR or POMC deficiency: single-arm, open-label, multicentre, phase 3 trials. The Lancet Diabetes & Endocrinology. Online first (2020). https://doi.org/10.1016/S2213-8587(20)30364-8
Haws, R., et al.Effect of setmelanotide, a melanocortin-4 receptor agonist, on obesity in Bardet-Biedl syndrome. Diabetes, Obesity and Metabolism, 10.1111/dom.14133 (2020). Advance online publication. https://doi.org/10.1111/dom.14133
Clément, K., et al. MC4R agonism promotes durable weight loss in patients with leptin receptor deficiency. Nat. Med. 24, 551–555 (2018). https://doi.org/10.1038/s41591-018-0015-9
Kühnen, P., et al. Proopiomelanocortin Deficiency Treated with a Melanocortin-4 Receptor Agonist. New England Journal of Medicine; 375:240-6. DOI: 10.1056/NEJMoa1512693(2016). https://www.nejm.org/doi/10.1056/NEJMoa1512693
Garfield, AS. et al. Role of central melanocortin pathways in energy homeostasis. Trends in Endocrinology and Metabolism: TEM, 203-215. DOI: 10.1016/j.tem.2009.02.002 (2009).https://doi.org/10.1016/j.tem.2009.02.002
To request a copy of an article, email medinfo@rhythmtx.com.
The Obesity Society’s ObesityWeek® 2020
“A Randomized Trial of a Once-Weekly Formulation of Setmelanotide in Individuals with Obesity,” an oral presentation by Gregory Gordon, MD, JD, Vice President, Clinical at Rhythm
Nov. 5, 2020 oral presentation slides
“Long-term Weight and Hunger Reduction With Setmelanotide in Individuals With POMC Deficiency Obesity,” a poster presentation by Karine Clément, MD, PhD, and Professor of Nutrition at Pitié-Salpêtrière Hospital and Sorbonne Université in Paris
Nov. 3, 2020 poster presentation
“Suicidality and Depression in Individuals With Genetic Obesity Treated With Setmelanotide,” a poster presentation by Peter Kühnen, MD, Institute for Experimental Pediatric Endocrinology, Charité Universitätsmedizin in Berlin
Nov. 3, 2020 poster presentation
The Obesity Society’s ObesityWeek® 2019
“Efficacy and Safety of the MC4R Agonist Setmelanotide in POMC Deficiency Obesity: A Phase 3 Trial,” presented by Peter Kühnen, M.D., Institute for Experimental Pediatric Endocrinology, Charité Universitäts medizin Berlin, Germany
Nov. 4 oral presentation slides
Nov. 7 poster presentation
“Efficacy and Safety of the MC4R Agonist Setmelanotide in LEPR Deficiency Obesity: A Phase 3 Trial,” oral presentation by Erica Van Den Akker, M.D., Ph.D., Erasmus MC-Sophia Children’s Hospital University in Rotterdam, Netherlands
Nov. 4 oral presentation slides
Nov. 7 poster presentation
Rhythm Pharmaceuticals, Inc.
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