Joanne E. Totosy de Zepetnek


Vice President,
Regulatory Affairs and Quality

Joanne “Jo” Totosy joined Rhythm as our Vice President of Regulatory Affairs and Quality in February 2019. She brings nearly 30 years of global experience in all phases of development including post-marketing and life cycle management, regulatory, and both clinical and preclinical development. Prior to joining Rhythm, Jo held leadership positions in global regulatory strategy at both Shire Pharmaceuticals and Novartis. She also served as Associate Deputy Director of Regulatory Affairs and Assistant Professor of Medicine at the University of Massachusetts Medical School’s MassBiologics division. Jo has worked in a wide variety of therapeutic areas, including vaccines, inflammation, metabolism/endocrine, rare diseases, transplantation, oncology, and companion diagnostics. Jo earned her Ph.D. in pharmacology at the University of Alberta, Edmonton, a Master of Science in physiology at the University of Ottawa, and her bachelor’s degree in zoology at Western University.